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Day: December 21, 2023

JAK of All Trades, Master of Some? New Research Highlights Tissue-Specific Roles of JAK Signaling

Mice engineered with a patient gene (JAK1 GOF: Neuron) show less lung inflammation, fewer immune cells, and reduced mucous production compared to controls CREDIT: Kim et al., Cell.

Janus kinase (JAK) inhibitors are revolutionizing the way certain inflammatory diseases such as atopic dermatitis (AD) are being treated, but a more nuanced approach may be needed in modulating JAK activity for conditions like asthma. This is the main takeaway message from a new study in the December 21, 2023, issue of Cell. For the […]

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