Hands down, isotretinoin is the most efficacious acne medication of all time, but not every patient needs it, says Shanna M. Miranti, MPAS, PA-C, a board-certified physician assistant at Riverchase Dermatology in Naples, FL. It’s essential to have a frank conversation about contraindications and side effects with potential patients. If a patient is a candidate for isotretinoin, prescribers must accurately document what they have previously tried and failed as part of the prior authorization process.